The effect of corpus callosum abnormalities on myelin development in the fetal brain using the fast macromolecular proton fraction mapping

INTRODUCTION: There is evidence, indicate early compensatory axonal remodeling connections in the prenatal period, providing a favorable neurological outcome isolated anomalies of corpus callosum (CC). Mapping macromolecular proton fraction (MPF) proven method quantitative determination myelin, which has been adapted for studies. OBJECTIVE: To investigate relationship between CC and myelination brain using fast mapping. MATERIALS AND METHODS: Fetal MR imaging were performed on 1.5 scanner (Achieva, Philips) 16-channel body coil. Of 66 fetal brains MRI, 12 studies selected with MT abnormalities (22.8±2.8, 19–28.5 WG) 21 without pathology (23.1±2.3, 20–29.5 WG). The images analyzed according to structural MRI data (T2-Ssh T1-GE, EPI, DWI, MYUR, T2-BFE-DYN) by two experienced radiologists. Fast-3D-MPF scan protocol MPF maps reconstruction was carried out specialized (open-source software: https://www.macroatomicmri.org /). Quantitative obtained choosing region interest (ROI) numerous structures bilateral (bridge, medulla oblongata, thalamus, cerebellum, cerebral hemispheres). Statistics: distinctions groups assessed repeated-measures analysis covariance (ANCOVA), Pearson correlation analysis. RESULTS: significantly increased group as compared controls (3.26±0.63% vs. 2.75±0.59%, р=0.001) cerebellum (2.02±0.55% 1.76±0.34%, р=0.006). In hemispheres significant GA observed (r=0.81, р=0.002), but absent (r=0.32, р=0.16). CONCLUSION: Primary increase well dependence large gestational age indicates that matter undergoes cases interhemispheric connections’ reduction.